藥物交互作用
Venetoclax + Voriconazole
嚴重程度: 禁忌併用
Venetoclax and Voriconazole: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Voriconazole increases venetoclax exposure, raising the risk of tumor lysis syndrome and neutropenia, especially during dose ramp-up. After ramp-up the combination may be used only with a substantial venetoclax dose reduction.
用白話說明這項交互作用的意義
Venetoclax and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Venetoclax belongs to Miscellaneous; Voriconazole belongs to Anti Fungals.
為什麼會發生
Strong CYP3A4 inhibition (and possible P-gp inhibition) reduces venetoclax clearance.
處置方式
Avoid during initiation and ramp-up in CLL/SLL. After ramp-up, reduce venetoclax dose per labeling and monitor blood counts and for toxicity.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Voriconazole 的其他交互作用
Venetoclax 的其他交互作用
常見問題
Can I take Venetoclax with Voriconazole?
MediHelp rates the interaction as contraindicated. Venetoclax and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Voriconazole increases venetoclax exposure, raising the risk of tumor lysis syndrome and neutropenia, especially during dose ramp-up. After ramp-up the combination may be used only with a substantial venetoclax dose reduction.
How serious is the interaction between Venetoclax and Voriconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid during initiation and ramp-up in CLL/SLL. After ramp-up, reduce venetoclax dose per labeling and monitor blood counts and for toxicity.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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