藥品參考
Zidovudine
Zidovudine is a medicine in the class anti virals. It is used for hiv.
- 藥物類別: Anti Virals
- 用途: hiv
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Anti Virals
- 常見劑型
- 膠囊, 錠劑, 溶液, 注射劑
- 常見規格
- 50 mg, 50 mg/5 ml, 100 mg
- 已知交互作用
- 84 (禁忌併用: 2 · 嚴重: 18 · 中度: 39 · 輕微: 25)
- 商品名
- 5
- 國家與市場
- 4
用途
作用方式
Inhibits thymidine kinase, Nucleoside Reverse Transcriptase Inhibitor (NRTI), Use with 3TC inhibits resistance
成人常用劑量（仿單摘要）
HIV Infection Treatment: 300 mg PO q12hr OR 200 mg PO q8hr (600 mg/day)
懷孕與哺乳
- 懷孕
- Safe Large registry data show no rise in birth defects. Long used to prevent mother-to-child HIV transmission, including IV during labour in some women. Transient raised lactate has been reported in exposed infants, without proven harm. Continue as prescribed in an HIV regimen.
- 哺乳
- Safe LactMed: well studied; low milk levels, most breastfed infants have undetectable blood levels, but some developed anaemia. US label: do not breastfeed (HIV). US/WHO guidance: with a sustained undetectable viral load, breastfeeding can be supported after counselling; otherwise formula or donor milk.
已通報的副作用
- Diarrhea
- Anorexia
- Anemia
- Fever
- Granulocytopenia
哪些人需要特別留意
- Risk of severe anemia and bone marrow depression; use with caution in patients with bone marrow compromise; hemoglobin reduction may occur 2-4 weeks
- Myopathy and myositis with pathological changes, similar to that produced by HIV-1 disease,associated with prolonged use of therapy
- Exacerbation of anemia due to ribavirin reported when zidovudine is part of HIV regimen; coadministration of ribavirin and zidovudine is not advised
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (84)
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
- Clozapine + Zidovudine Major
- Deferiprone + Zidovudine Major
- Doxorubicin + Zidovudine Major
- Elivaldogene autotemcel + Zidovudine Major
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Zidovudine 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
在網頁版免費試用 Pro+ 14 天，無需信用卡。
同類別的其他藥品
常見問題
What is Zidovudine used for?
Zidovudine is a medicine in the class anti virals. It is used for HIV.
What side effects have been reported with Zidovudine?
Diarrhea, Anorexia, Anemia, Fever, Granulocytopenia.
Can Zidovudine be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Large registry data show no rise in birth defects. Long used to prevent mother-to-child HIV transmission, including IV during labour in some women. Transient raised lactate has been reported in exposed infants, without proven harm. Continue as prescribed in an HIV regimen. Breastfeeding: Safe. LactMed: well studied; low milk levels, most breastfed infants have undetectable blood levels, but some developed anaemia. US label: do not breastfeed (HIV). US/WHO guidance: with a sustained undetectable viral load, breastfeeding can be supported after counselling; otherwise formula or donor milk.
What does Zidovudine interact with?
MediHelp lists 84 known interactions for Zidovudine. Contraindicated: 2 · Major: 18 · Moderate: 39 · Minor: 25. The most serious include Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Atidarsagene autotemcel.
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