藥物交互作用
Deferiprone + Zidovudine
嚴重程度: 嚴重
Deferiprone and Zidovudine: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Both agents can cause neutropenia, and deferiprone carries a boxed warning for agranulocytosis. Together they increase the risk of severe neutropenia and infection.
用白話說明這項交互作用的意義
Deferiprone and Zidovudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferiprone belongs to Miscellaneous; Zidovudine belongs to Anti Virals.
為什麼會發生
Additive myelosuppressive effects on neutrophil production.
處置方式
Avoid combining where possible, using an alternative antiretroviral. If unavoidable, monitor the absolute neutrophil count more frequently and interrupt deferiprone if neutropenia occurs.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Zidovudine 的其他交互作用
Deferiprone 的其他交互作用
常見問題
Can I take Deferiprone with Zidovudine?
MediHelp rates the interaction as major. Deferiprone and Zidovudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can cause neutropenia, and deferiprone carries a boxed warning for agranulocytosis. Together they increase the risk of severe neutropenia and infection.
How serious is the interaction between Deferiprone and Zidovudine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, using an alternative antiretroviral. If unavoidable, monitor the absolute neutrophil count more frequently and interrupt deferiprone if neutropenia occurs.
What other medicines interact with Zidovudine?
MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Atidarsagene autotemcel. The full list is on the Zidovudine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
