藥物交互作用
Cisplatin + Zidovudine
嚴重程度: 嚴重
Cisplatin and Zidovudine: major interaction.
最後更新
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摘要
Both agents can suppress the bone marrow, so the combination raises the risk of anemia and neutropenia. Cisplatin nephrotoxicity may also affect zidovudine clearance.
用白話說明這項交互作用的意義
Cisplatin and Zidovudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cisplatin belongs to Oncology; Zidovudine belongs to Anti Virals.
為什麼會發生
Additive bone marrow suppression.
處置方式
Monitor full blood counts frequently and consider an alternative to zidovudine during chemotherapy. Reduce doses or provide growth factor support as needed.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Zidovudine 的其他交互作用
Cisplatin 的其他交互作用
常見問題
Can I take Cisplatin with Zidovudine?
MediHelp rates the interaction as major. Cisplatin and Zidovudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can suppress the bone marrow, so the combination raises the risk of anemia and neutropenia. Cisplatin nephrotoxicity may also affect zidovudine clearance.
How serious is the interaction between Cisplatin and Zidovudine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor full blood counts frequently and consider an alternative to zidovudine during chemotherapy. Reduce doses or provide growth factor support as needed.
What other medicines interact with Zidovudine?
MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Atidarsagene autotemcel. The full list is on the Zidovudine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
