藥物交互作用
Abacavir + Ribavirin
嚴重程度: 中度
Abacavir and Ribavirin: moderate interaction.
最後更新
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摘要
Ribavirin and nucleoside analogues such as abacavir can both disturb mitochondrial function. The combination may raise the risk of lactic acidosis and hepatic decompensation, particularly in patients with HIV/HCV coinfection and advanced liver disease.
用白話說明這項交互作用的意義
Abacavir and Ribavirin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Abacavir belongs to Anti Virals; Ribavirin belongs to Anti Virals.
為什麼會發生
Possible additive mitochondrial toxicity; ribavirin may also alter intracellular nucleoside phosphorylation, though this is not firmly established for abacavir.
處置方式
Monitor lactate, liver function and clinical signs of lactic acidosis, especially in cirrhosis. Stop the offending agents if symptomatic hyperlactatemia or hepatic decompensation develops.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Ribavirin 的其他交互作用
Abacavir 的其他交互作用
常見問題
Can I take Abacavir with Ribavirin?
MediHelp rates the interaction as moderate. Abacavir and Ribavirin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribavirin and nucleoside analogues such as abacavir can both disturb mitochondrial function. The combination may raise the risk of lactic acidosis and hepatic decompensation, particularly in patients with HIV/HCV coinfection and advanced liver disease.
How serious is the interaction between Abacavir and Ribavirin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lactate, liver function and clinical signs of lactic acidosis, especially in cirrhosis. Stop the offending agents if symptomatic hyperlactatemia or hepatic decompensation develops.
What other medicines interact with Ribavirin?
MediHelp also lists interactions of Ribavirin with, for example, Didanosine, Stavudine, Zidovudine. The full list is on the Ribavirin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
