藥物交互作用
Acalabrutinib + Calcium carbonate
嚴重程度: 中度
Acalabrutinib and Calcium carbonate: moderate interaction.
最後更新
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摘要
Calcium carbonate raises gastric pH, and acalabrutinib capsules dissolve less well at higher pH. This can lower exposure and reduce efficacy.
用白話說明這項交互作用的意義
Acalabrutinib and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acalabrutinib belongs to Oncology; Calcium carbonate belongs to Gastrointestinal Tract.
為什麼會發生
Elevated gastric pH reduces the pH-dependent solubility and absorption of acalabrutinib.
處置方式
Take acalabrutinib at least 2 hours before the antacid. Avoid proton pump inhibitors with acalabrutinib capsules.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Calcium carbonate 的其他交互作用
Acalabrutinib 的其他交互作用
常見問題
Can I take Acalabrutinib with Calcium carbonate?
MediHelp rates the interaction as moderate. Acalabrutinib and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium carbonate raises gastric pH, and acalabrutinib capsules dissolve less well at higher pH. This can lower exposure and reduce efficacy.
How serious is the interaction between Acalabrutinib and Calcium carbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take acalabrutinib at least 2 hours before the antacid. Avoid proton pump inhibitors with acalabrutinib capsules.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Alendronate, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Calcium carbonate page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
