藥物交互作用
Amlodipine-hydrochlorothiazide-valsartan + Calcium carbonate
嚴重程度: 中度
Amlodipine-hydrochlorothiazide-valsartan and Calcium carbonate: moderate interaction.
最後更新
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摘要
Thiazides reduce urinary calcium excretion, and with calcium carbonate this can cause hypercalcemia and milk-alkali syndrome, especially with high doses or renal impairment. High-dose calcium may also reduce calcium channel blocker effects, although this is rarely clinically significant at usual intakes.
用白話說明這項交互作用的意義
Amlodipine-hydrochlorothiazide-valsartan and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Calcium carbonate belongs to Gastrointestinal Tract.
為什麼會發生
Thiazide-reduced renal calcium excretion plus calcium load leading to hypercalcemia.
處置方式
Monitor serum calcium and renal function, particularly with high calcium doses or long-term use. Reduce calcium supplementation if hypercalcemia develops.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Amlodipine-hydrochlorothiazide-valsartan 的其他交互作用
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan 禁忌併用
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide 禁忌併用
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan 禁忌併用
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan 嚴重
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan 嚴重
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan 嚴重
Calcium carbonate 的其他交互作用
常見問題
Can I take Amlodipine-hydrochlorothiazide-valsartan with Calcium carbonate?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides reduce urinary calcium excretion, and with calcium carbonate this can cause hypercalcemia and milk-alkali syndrome, especially with high doses or renal impairment. High-dose calcium may also reduce calcium channel blocker effects, although this is rarely clinically significant at usual intakes.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Calcium carbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and renal function, particularly with high calcium doses or long-term use. Reduce calcium supplementation if hypercalcemia develops.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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