藥物交互作用
Alendronate + Calcium carbonate
嚴重程度: 中度
Alendronate and Calcium carbonate: moderate interaction.
最後更新
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摘要
Oral calcium salts bind alendronate in the gut and markedly reduce its already low absorption. This can lead to loss of bisphosphonate efficacy.
用白話說明這項交互作用的意義
Alendronate and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alendronate belongs to Musculoskeletal; Calcium carbonate belongs to Gastrointestinal Tract.
為什麼會發生
Divalent calcium cations form insoluble complexes with alendronate in the gastrointestinal tract, reducing absorption.
處置方式
Take alendronate fasting with plain water at least 30 minutes before calcium or any other food, drink or medication. Give calcium supplements later in the day.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Calcium carbonate 的其他交互作用
Alendronate 的其他交互作用
常見問題
Can I take Alendronate with Calcium carbonate?
MediHelp rates the interaction as moderate. Alendronate and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral calcium salts bind alendronate in the gut and markedly reduce its already low absorption. This can lead to loss of bisphosphonate efficacy.
How serious is the interaction between Alendronate and Calcium carbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take alendronate fasting with plain water at least 30 minutes before calcium or any other food, drink or medication. Give calcium supplements later in the day.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Calcium carbonate page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
