藥物交互作用
Azilsartan-chlorthalidone + Calcium carbonate
嚴重程度: 中度
Azilsartan-chlorthalidone and Calcium carbonate: moderate interaction.
最後更新
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摘要
Chlorthalidone decreases urinary calcium excretion, and with calcium supplements this can lead to hypercalcemia. High calcium carbonate doses may also cause metabolic alkalosis, particularly with alkali intake.
用白話說明這項交互作用的意義
Azilsartan-chlorthalidone and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Calcium carbonate belongs to Gastrointestinal Tract.
為什麼會發生
Thiazide-like reduction of renal calcium excretion adds to calcium load from supplementation.
處置方式
Monitor serum calcium periodically and reduce calcium dose if levels rise. Use caution with high doses, especially in renal impairment.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Azilsartan-chlorthalidone 的其他交互作用
Calcium carbonate 的其他交互作用
常見問題
Can I take Azilsartan-chlorthalidone with Calcium carbonate?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone decreases urinary calcium excretion, and with calcium supplements this can lead to hypercalcemia. High calcium carbonate doses may also cause metabolic alkalosis, particularly with alkali intake.
How serious is the interaction between Azilsartan-chlorthalidone and Calcium carbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium periodically and reduce calcium dose if levels rise. Use caution with high doses, especially in renal impairment.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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