藥物交互作用
Acetylsalicylic acid + Ticlopidine
嚴重程度: 嚴重
Acetylsalicylic acid and Ticlopidine: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Combining aspirin with ticlopidine increases the risk of bleeding because both impair platelet function through different pathways. The pair is sometimes used deliberately, for example after coronary stenting, but ticlopidine carries additional hematologic toxicity and has largely been replaced by other agents.
用白話說明這項交互作用的意義
Acetylsalicylic acid and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Acetylsalicylic acid belongs to Musculoskeletal; Ticlopidine belongs to Cardiovascular.
為什麼會發生
Additive antiplatelet effects from irreversible COX-1 inhibition by aspirin and P2Y12 receptor blockade by ticlopidine.
處置方式
Use only when dual antiplatelet therapy is clearly indicated, and prefer clopidogrel or another P2Y12 inhibitor instead of ticlopidine. Monitor for bleeding and follow blood counts regularly.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Acetylsalicylic acid 的其他交互作用
Ticlopidine 的其他交互作用
常見問題
Can I take Acetylsalicylic acid with Ticlopidine?
MediHelp rates the interaction as major. Acetylsalicylic acid and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining aspirin with ticlopidine increases the risk of bleeding because both impair platelet function through different pathways. The pair is sometimes used deliberately, for example after coronary stenting, but ticlopidine carries additional hematologic toxicity and has largely been replaced by other agents.
How serious is the interaction between Acetylsalicylic acid and Ticlopidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only when dual antiplatelet therapy is clearly indicated, and prefer clopidogrel or another P2Y12 inhibitor instead of ticlopidine. Monitor for bleeding and follow blood counts regularly.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
