藥物交互作用
Mavacamten + Ticlopidine
嚴重程度: 禁忌併用
Mavacamten and Ticlopidine: contraindicated interaction.
最後更新
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摘要
Ticlopidine inhibits CYP2C19, which is the main route of mavacamten metabolism, and may raise its exposure. Excess mavacamten can reduce ejection fraction and lead to heart failure from systolic dysfunction. The labeling contraindicates moderate to strong CYP2C19 inhibitors.
用白話說明這項交互作用的意義
Mavacamten and Ticlopidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Mavacamten belongs to Cardiovascular; Ticlopidine belongs to Cardiovascular.
為什麼會發生
Inhibition of CYP2C19 by ticlopidine reduces mavacamten clearance.
處置方式
Avoid the combination and choose an alternative antiplatelet drug if possible. If it cannot be avoided, monitor LVEF closely and consider mavacamten dose reduction or interruption.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Ticlopidine 的其他交互作用
Mavacamten 的其他交互作用
常見問題
Can I take Mavacamten with Ticlopidine?
MediHelp rates the interaction as contraindicated. Mavacamten and Ticlopidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ticlopidine inhibits CYP2C19, which is the main route of mavacamten metabolism, and may raise its exposure. Excess mavacamten can reduce ejection fraction and lead to heart failure from systolic dysfunction. The labeling contraindicates moderate to strong CYP2C19 inhibitors.
How serious is the interaction between Mavacamten and Ticlopidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative antiplatelet drug if possible. If it cannot be avoided, monitor LVEF closely and consider mavacamten dose reduction or interruption.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Abrocitinib, Acetylsalicylic acid, Apixaban. The full list is on the Ticlopidine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
