藥物交互作用
Aliskiren + Sparsentan
嚴重程度: 禁忌併用
Aliskiren and Sparsentan: contraindicated interaction.
最後更新
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摘要
Sparsentan blocks both the endothelin and angiotensin II receptors, and adding aliskiren produces further renin-angiotensin blockade. This increases the risk of hypotension, hyperkalemia and kidney injury.
用白話說明這項交互作用的意義
Aliskiren and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Aliskiren belongs to Cardiovascular; Sparsentan belongs to Genitourinary.
為什麼會發生
Additive dual renin-angiotensin system inhibition with endothelin receptor blockade.
處置方式
Do not combine; avoid other RAS blockers with sparsentan. Monitor blood pressure, potassium and renal function in patients on sparsentan.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Sparsentan 的其他交互作用
Aliskiren 的其他交互作用
常見問題
Can I take Aliskiren with Sparsentan?
MediHelp rates the interaction as contraindicated. Aliskiren and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sparsentan blocks both the endothelin and angiotensin II receptors, and adding aliskiren produces further renin-angiotensin blockade. This increases the risk of hypotension, hyperkalemia and kidney injury.
How serious is the interaction between Aliskiren and Sparsentan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; avoid other RAS blockers with sparsentan. Monitor blood pressure, potassium and renal function in patients on sparsentan.
What other medicines interact with Sparsentan?
MediHelp also lists interactions of Sparsentan with, for example, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide, Amlodipine-olmesartan. The full list is on the Sparsentan page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
