藥品參考
Sparsentan
Sparsentan is a medicine in the class genitourinary. It is used for nephropathy.
- 藥物類別: Genitourinary
- 用途: nephropathy
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Genitourinary
- ATC 代碼
- C09XX01
- 常見劑型
- 錠劑
- 已知交互作用
- 139 (禁忌併用: 24 · 嚴重: 30 · 中度: 68 · 輕微: 17)
- 商品名
- 2
- 國家與市場
- 2
用途
作用方式
Single molecule that antagonizes the endothelin type A receptor (ETAR) and the angiotensin II type 1 receptor (AT1R), both thought to be involved in the pathogenesis of IgAN and FSGS.
成人常用劑量（仿單摘要）
IgAN (adults): start 200 mg orally once daily; after 14 days increase to 400 mg once daily, as tolerated
懷孕與哺乳
- 懷孕
- Unsafe Contraindicated in pregnancy: in rats it caused craniofacial and skeletal malformations and fetal death at 10 times human exposure (endothelin and angiotensin blockade). Exclude pregnancy before and during treatment; use effective contraception until 1 month (EU) or 2 weeks (US) after stopping.
- 哺乳
- Unknown No human milk data. US label: do not breastfeed (possible infant low blood pressure); EU: should not be used while breastfeeding. LactMed has no data and repeats the maker's advice. Prefer not to breastfeed during treatment.
已通報的副作用
- Hyperkalemia
- Hypotension (including orthostatic hypotension)
- Peripheral edema
- Dizziness
- Anemia
- Acute kidney injury
黑框警語
- Hepatotoxicity: available only through the restricted FILSPARI REMS. Aminotransferase elevations of at least 3-times ULN occurred in up to 3.5% of patients. Measure transaminases and bilirubin before treatment and every 3 months; interrupt and monitor if above 3-times ULN. Generally avoid in patients with baseline aminotransferases above 3-times ULN.
禁忌症
- Pregnancy
- Concomitant use with ARBs, ERAs, or aliskiren
哪些人需要特別留意
- Hepatotoxicity: monitor aminotransferases and bilirubin; stop and seek medical attention if symptoms of liver injury occur.
- Hypotension: consider adjusting other antihypertensives; consider dose reduction or interruption if it develops.
- Acute kidney injury: monitor kidney function periodically; patients with renal artery stenosis, CKD, severe heart failure or volume depletion are at particular risk.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (139)
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
- Bosentan + Sparsentan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Sparsentan 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
在網頁版免費試用 Pro+ 14 天，無需信用卡。
常見問題
What is Sparsentan used for?
Sparsentan is a medicine in the class genitourinary. It is used for Nephropathy.
What side effects have been reported with Sparsentan?
Hyperkalemia, Hypotension (including orthostatic hypotension), Peripheral edema, Dizziness, Anemia, Acute kidney injury. Serious warning: Hepatotoxicity: available only through the restricted FILSPARI REMS.
Can Sparsentan be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Contraindicated in pregnancy: in rats it caused craniofacial and skeletal malformations and fetal death at 10 times human exposure (endothelin and angiotensin blockade). Exclude pregnancy before and during treatment; use effective contraception until 1 month (EU) or 2 weeks (US) after stopping. Breastfeeding: Unknown. No human milk data. US label: do not breastfeed (possible infant low blood pressure); EU: should not be used while breastfeeding. LactMed has no data and repeats the maker's advice. Prefer not to breastfeed during treatment.
What does Sparsentan interact with?
MediHelp lists 139 known interactions for Sparsentan. Contraindicated: 24 · Major: 30 · Moderate: 68 · Minor: 17. The most serious include Aliskiren, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan.
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