藥物交互作用
Azilsartan + Sparsentan
嚴重程度: 禁忌併用
Azilsartan and Sparsentan: contraindicated interaction.
最後更新
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摘要
Sparsentan is itself a dual endothelin and angiotensin II receptor antagonist, so adding an ARB produces excessive blockade of the angiotensin pathway. This raises the risk of hypotension, syncope, hyperkalemia and deterioration of renal function, including acute kidney injury.
用白話說明這項交互作用的意義
Azilsartan and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Azilsartan belongs to Cardiovascular; Sparsentan belongs to Genitourinary.
為什麼會發生
Additive pharmacodynamic angiotensin II type 1 receptor blockade, since sparsentan already has ARB activity.
處置方式
Do not combine; stop the ARB before starting sparsentan. Sparsentan labeling contraindicates concomitant ARBs, ACE inhibitors and aliskiren.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Azilsartan 的其他交互作用
Sparsentan 的其他交互作用
常見問題
Can I take Azilsartan with Sparsentan?
MediHelp rates the interaction as contraindicated. Azilsartan and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sparsentan is itself a dual endothelin and angiotensin II receptor antagonist, so adding an ARB produces excessive blockade of the angiotensin pathway. This raises the risk of hypotension, syncope, hyperkalemia and deterioration of renal function, including acute kidney injury.
How serious is the interaction between Azilsartan and Sparsentan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; stop the ARB before starting sparsentan. Sparsentan labeling contraindicates concomitant ARBs, ACE inhibitors and aliskiren.
What other medicines interact with Azilsartan?
MediHelp also lists interactions of Azilsartan with, for example, Aliskiren, Amifostine, Amlodipine-benazepril. The full list is on the Azilsartan page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
