藥物交互作用
Allopurinol + Ethambutol
嚴重程度: 中度
Allopurinol and Ethambutol: moderate interaction.
最後更新
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摘要
Ethambutol reduces renal urate excretion and can raise serum uric acid, sometimes precipitating gout flares. This can counteract the urate-lowering benefit of allopurinol, so the allopurinol dose may prove insufficient.
用白話說明這項交互作用的意義
Allopurinol and Ethambutol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Allopurinol belongs to Genitourinary; Ethambutol belongs to Anti Bacterial.
為什麼會發生
Ethambutol decreases renal tubular excretion of uric acid, opposing the effect of xanthine oxidase inhibition.
處置方式
Monitor serum uric acid and gout symptoms during ethambutol therapy and increase the allopurinol dose if needed to reach the urate target.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Allopurinol 的其他交互作用
Ethambutol 的其他交互作用
常見問題
Can I take Allopurinol with Ethambutol?
MediHelp rates the interaction as moderate. Allopurinol and Ethambutol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethambutol reduces renal urate excretion and can raise serum uric acid, sometimes precipitating gout flares. This can counteract the urate-lowering benefit of allopurinol, so the allopurinol dose may prove insufficient.
How serious is the interaction between Allopurinol and Ethambutol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum uric acid and gout symptoms during ethambutol therapy and increase the allopurinol dose if needed to reach the urate target.
What other medicines interact with Allopurinol?
MediHelp also lists interactions of Allopurinol with, for example, Azathioprine, Didanosine, Mercaptopurine. The full list is on the Allopurinol page.
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