藥物交互作用
Ethambutol + Probenecid
嚴重程度: 中度
Ethambutol and Probenecid: moderate interaction.
最後更新
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摘要
Ethambutol reduces renal urate excretion and can cause hyperuricemia or provoke gout. This opposes the urate-lowering effect of probenecid and may require adjustment of gout therapy.
用白話說明這項交互作用的意義
Ethambutol and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethambutol belongs to Anti Bacterial; Probenecid belongs to Genitourinary.
為什麼會發生
Ethambutol decreases renal tubular urate excretion, pharmacodynamically antagonizing the uricosuric action of probenecid.
處置方式
Monitor serum uric acid and gout symptoms during ethambutol treatment. Increase the uricosuric dose or switch to another urate-lowering agent if control is lost.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Probenecid 的其他交互作用
Ethambutol 的其他交互作用
常見問題
Can I take Ethambutol with Probenecid?
MediHelp rates the interaction as moderate. Ethambutol and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethambutol reduces renal urate excretion and can cause hyperuricemia or provoke gout. This opposes the urate-lowering effect of probenecid and may require adjustment of gout therapy.
How serious is the interaction between Ethambutol and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum uric acid and gout symptoms during ethambutol treatment. Increase the uricosuric dose or switch to another urate-lowering agent if control is lost.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
