藥物交互作用
Allopurinol + Pentostatin
嚴重程度: 中度
Allopurinol and Pentostatin: moderate interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Both drugs can cause skin reactions, and a fatal hypersensitivity vasculitis has been reported with combined use. Overall rash incidence did not clearly increase, but the potential severity is significant.
用白話說明這項交互作用的意義
Allopurinol and Pentostatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Allopurinol belongs to Genitourinary; Pentostatin belongs to Oncology.
為什麼會發生
Possible additive hypersensitivity reactions; the mechanism is not well established.
處置方式
Monitor for rash and signs of hypersensitivity, and stop allopurinol or pentostatin if a serious reaction develops.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pentostatin 的其他交互作用
Allopurinol 的其他交互作用
常見問題
Can I take Allopurinol with Pentostatin?
MediHelp rates the interaction as moderate. Allopurinol and Pentostatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause skin reactions, and a fatal hypersensitivity vasculitis has been reported with combined use. Overall rash incidence did not clearly increase, but the potential severity is significant.
How serious is the interaction between Allopurinol and Pentostatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for rash and signs of hypersensitivity, and stop allopurinol or pentostatin if a serious reaction develops.
What other medicines interact with Pentostatin?
MediHelp also lists interactions of Pentostatin with, for example, Carmustine, Etoposide, Fludarabine. The full list is on the Pentostatin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
