藥物交互作用
Amantadine + Amisulpride
嚴重程度: 中度
Amantadine and Amisulpride: moderate interaction.
最後更新
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摘要
Amantadine enhances dopaminergic transmission while amisulpride blocks dopamine D2/D3 receptors, so each can blunt the effect of the other. Antipsychotic efficacy may be reduced and parkinsonian symptoms may worsen, while dopaminergic agents can aggravate psychosis.
用白話說明這項交互作用的意義
Amantadine and Amisulpride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amantadine belongs to Anti Virals; Amisulpride belongs to Central Nervous System.
為什麼會發生
Pharmacodynamic antagonism between dopamine-enhancing amantadine and the D2/D3 antagonist amisulpride.
處置方式
Avoid the combination when possible, especially in Parkinson disease; if both are needed, monitor psychiatric symptoms and motor function and adjust doses accordingly.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Amantadine 的其他交互作用
Amisulpride 的其他交互作用
常見問題
Can I take Amantadine with Amisulpride?
MediHelp rates the interaction as moderate. Amantadine and Amisulpride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amantadine enhances dopaminergic transmission while amisulpride blocks dopamine D2/D3 receptors, so each can blunt the effect of the other. Antipsychotic efficacy may be reduced and parkinsonian symptoms may worsen, while dopaminergic agents can aggravate psychosis.
How serious is the interaction between Amantadine and Amisulpride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible, especially in Parkinson disease; if both are needed, monitor psychiatric symptoms and motor function and adjust doses accordingly.
What other medicines interact with Amantadine?
MediHelp also lists interactions of Amantadine with, for example, Ethanol, Memantine-donepezil, Metoclopramide. The full list is on the Amantadine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
