藥物交互作用
Amifampridine + Benzathine penicillin g
嚴重程度: 輕微
Amifampridine and Benzathine penicillin g: minor interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Amifampridine carries a dose-related risk of seizures. Penicillins can lower the seizure threshold, mainly at high doses or with renal impairment, so the combined risk may be higher. Intramuscular depot benzathine penicillin gives low peak levels, so the practical risk is small.
用白話說明這項交互作用的意義
Amifampridine and Benzathine penicillin g have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amifampridine belongs to Central Nervous System; Benzathine penicillin g belongs to Anti Bacterial.
為什麼會發生
Additive pharmacodynamic lowering of seizure threshold (amifampridine potassium channel blockade plus penicillin GABA-A antagonism).
處置方式
No routine change is needed. Monitor for seizure activity, particularly in patients with renal impairment, a seizure history, or when high-dose penicillin is used.
可向藥師詢問的問題
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Benzathine penicillin g 的其他交互作用
Amifampridine 的其他交互作用
常見問題
Can I take Amifampridine with Benzathine penicillin g?
MediHelp rates the interaction as minor. Amifampridine and Benzathine penicillin g have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amifampridine carries a dose-related risk of seizures. Penicillins can lower the seizure threshold, mainly at high doses or with renal impairment, so the combined risk may be higher. Intramuscular depot benzathine penicillin gives low peak levels, so the practical risk is small.
How serious is the interaction between Amifampridine and Benzathine penicillin g?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor for seizure activity, particularly in patients with renal impairment, a seizure history, or when high-dose penicillin is used.
What other medicines interact with Benzathine penicillin g?
MediHelp also lists interactions of Benzathine penicillin g with, for example, Cholera vaccine, Microbiota, Omadacycline. The full list is on the Benzathine penicillin g page.
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