藥物交互作用
Benzathine penicillin g + Vadadustat
嚴重程度: 中度
Benzathine penicillin g and Vadadustat: moderate interaction.
最後更新
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摘要
Penicillin G can inhibit the renal transporters OAT1 and OAT3, which are involved in vadadustat elimination. Vadadustat exposure may therefore increase, raising the risk of an excessive hemoglobin rise and adverse effects. The clinical significance is likely small with benzathine penicillin because of its low and prolonged serum levels.
用白話說明這項交互作用的意義
Benzathine penicillin g and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benzathine penicillin g belongs to Anti Bacterial; Vadadustat belongs to Endocrine.
為什麼會發生
Penicillin G competes for OAT1/OAT3-mediated renal transport, which may reduce vadadustat clearance.
處置方式
Monitor hemoglobin response and for vadadustat adverse reactions during concurrent use. Reduce the vadadustat dose if hemoglobin rises too rapidly.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Benzathine penicillin g 的其他交互作用
Vadadustat 的其他交互作用
常見問題
Can I take Benzathine penicillin g with Vadadustat?
MediHelp rates the interaction as moderate. Benzathine penicillin g and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Penicillin G can inhibit the renal transporters OAT1 and OAT3, which are involved in vadadustat elimination. Vadadustat exposure may therefore increase, raising the risk of an excessive hemoglobin rise and adverse effects. The clinical significance is likely small with benzathine penicillin because of its low and prolonged serum levels.
How serious is the interaction between Benzathine penicillin g and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin response and for vadadustat adverse reactions during concurrent use. Reduce the vadadustat dose if hemoglobin rises too rapidly.
What other medicines interact with Benzathine penicillin g?
MediHelp also lists interactions of Benzathine penicillin g with, for example, Cholera vaccine, Microbiota, Omadacycline. The full list is on the Benzathine penicillin g page.
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