藥物交互作用
Amikacin + Pancuronium
嚴重程度: 嚴重
Amikacin and Pancuronium: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Amikacin has neuromuscular blocking activity and can intensify and prolong pancuronium-induced paralysis. This may lead to delayed recovery, residual weakness and respiratory depression or apnea.
用白話說明這項交互作用的意義
Amikacin and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amikacin belongs to Anti Bacterial; Pancuronium belongs to Musculoskeletal.
為什麼會發生
Additive neuromuscular blockade through reduced presynaptic acetylcholine release and postsynaptic receptor blockade.
處置方式
Monitor neuromuscular function with train-of-four and reduce pancuronium dosing. Keep ventilatory support available until full recovery is confirmed.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pancuronium 的其他交互作用
Amikacin 的其他交互作用
常見問題
Can I take Amikacin with Pancuronium?
MediHelp rates the interaction as major. Amikacin and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amikacin has neuromuscular blocking activity and can intensify and prolong pancuronium-induced paralysis. This may lead to delayed recovery, residual weakness and respiratory depression or apnea.
How serious is the interaction between Amikacin and Pancuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with train-of-four and reduce pancuronium dosing. Keep ventilatory support available until full recovery is confirmed.
What other medicines interact with Pancuronium?
MediHelp also lists interactions of Pancuronium with, for example, Bacitracin-neomycin-polymyxin, Capreomycin, Clindamycin. The full list is on the Pancuronium page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
