藥物交互作用
Gentamicin + Pancuronium
嚴重程度: 嚴重
Gentamicin and Pancuronium: major interaction.
最後更新
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摘要
Gentamicin can augment and prolong neuromuscular blockade from pancuronium. This may cause delayed recovery, residual paralysis and respiratory depression after surgery.
用白話說明這項交互作用的意義
Gentamicin and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gentamicin belongs to Anti Bacterial; Pancuronium belongs to Musculoskeletal.
為什麼會發生
Additive neuromuscular blockade through reduced presynaptic acetylcholine release and postsynaptic receptor blockade.
處置方式
Use quantitative neuromuscular monitoring and reduce pancuronium dose. Keep ventilatory support available until full recovery, and consider a non-aminoglycoside alternative.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pancuronium 的其他交互作用
Gentamicin 的其他交互作用
常見問題
Can I take Gentamicin with Pancuronium?
MediHelp rates the interaction as major. Gentamicin and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gentamicin can augment and prolong neuromuscular blockade from pancuronium. This may cause delayed recovery, residual paralysis and respiratory depression after surgery.
How serious is the interaction between Gentamicin and Pancuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use quantitative neuromuscular monitoring and reduce pancuronium dose. Keep ventilatory support available until full recovery, and consider a non-aminoglycoside alternative.
What other medicines interact with Pancuronium?
MediHelp also lists interactions of Pancuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Pancuronium page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
