藥物交互作用
Amikacin + Vancomycin
嚴重程度: 嚴重
Amikacin and Vancomycin: major interaction.
最後更新
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摘要
Both drugs can injure the kidneys, and amikacin also damages the inner ear. Used together they carry a higher rate of acute kidney injury than either alone, and renal decline further raises aminoglycoside levels and ototoxicity risk.
用白話說明這項交互作用的意義
Amikacin and Vancomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amikacin belongs to Anti Bacterial; Vancomycin belongs to Anti Bacterial.
為什麼會發生
Additive nephrotoxicity from proximal tubular injury, with reduced clearance increasing aminoglycoside exposure.
處置方式
Avoid the combination where alternatives exist; otherwise monitor serum creatinine frequently and use therapeutic drug monitoring of both drugs. Dose to renal function and consider audiology monitoring for prolonged courses.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Vancomycin 的其他交互作用
Amikacin 的其他交互作用
常見問題
Can I take Amikacin with Vancomycin?
MediHelp rates the interaction as major. Amikacin and Vancomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can injure the kidneys, and amikacin also damages the inner ear. Used together they carry a higher rate of acute kidney injury than either alone, and renal decline further raises aminoglycoside levels and ototoxicity risk.
How serious is the interaction between Amikacin and Vancomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where alternatives exist; otherwise monitor serum creatinine frequently and use therapeutic drug monitoring of both drugs. Dose to renal function and consider audiology monitoring for prolonged courses.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Bacitracin, Capreomycin, Cephaloridine. The full list is on the Vancomycin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
