藥物交互作用
Cisplatin + Vancomycin
嚴重程度: 嚴重
Cisplatin and Vancomycin: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Cisplatin is markedly nephrotoxic and ototoxic, and vancomycin adds further renal risk. The combination raises the likelihood of acute kidney injury, and reduced clearance may in turn increase vancomycin levels and cisplatin-related hearing loss.
用白話說明這項交互作用的意義
Cisplatin and Vancomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cisplatin belongs to Oncology; Vancomycin belongs to Anti Bacterial.
為什麼會發生
Additive proximal tubular toxicity, with reduced renal clearance increasing exposure to both drugs.
處置方式
Use an alternative to vancomycin when possible. If necessary, monitor serum creatinine, magnesium and vancomycin levels closely, ensure hydration, and consider audiometry.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Vancomycin 的其他交互作用
Cisplatin 的其他交互作用
常見問題
Can I take Cisplatin with Vancomycin?
MediHelp rates the interaction as major. Cisplatin and Vancomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cisplatin is markedly nephrotoxic and ototoxic, and vancomycin adds further renal risk. The combination raises the likelihood of acute kidney injury, and reduced clearance may in turn increase vancomycin levels and cisplatin-related hearing loss.
How serious is the interaction between Cisplatin and Vancomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative to vancomycin when possible. If necessary, monitor serum creatinine, magnesium and vancomycin levels closely, ensure hydration, and consider audiometry.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
