藥物交互作用
Amiodarone + Levoketoconazole
嚴重程度: 禁忌併用
Amiodarone and Levoketoconazole: contraindicated interaction.
最後更新
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摘要
Both drugs prolong the QT interval, and levoketoconazole also inhibits CYP3A4 and may raise amiodarone concentrations. The combined effect increases the risk of torsades de pointes and other serious ventricular arrhythmias.
用白話說明這項交互作用的意義
Amiodarone and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amiodarone belongs to Cardiovascular; Levoketoconazole belongs to Endocrine.
為什麼會發生
Additive QT prolongation plus CYP3A4 inhibition by levoketoconazole reducing amiodarone metabolism.
處置方式
Avoid concurrent use; choose an alternative antiarrhythmic or cortisol-lowering therapy. If unavoidable, obtain ECG monitoring and correct potassium and magnesium.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Amiodarone 的其他交互作用
Levoketoconazole 的其他交互作用
常見問題
Can I take Amiodarone with Levoketoconazole?
MediHelp rates the interaction as contraindicated. Amiodarone and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and levoketoconazole also inhibits CYP3A4 and may raise amiodarone concentrations. The combined effect increases the risk of torsades de pointes and other serious ventricular arrhythmias.
How serious is the interaction between Amiodarone and Levoketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; choose an alternative antiarrhythmic or cortisol-lowering therapy. If unavoidable, obtain ECG monitoring and correct potassium and magnesium.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
