藥物交互作用
Clarithromycin + Levoketoconazole
嚴重程度: 禁忌併用
Clarithromycin and Levoketoconazole: contraindicated interaction.
最後更新
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摘要
Levoketoconazole is a strong CYP3A4 inhibitor that can raise clarithromycin levels, and both drugs prolong the QT interval. Levoketoconazole is contraindicated with other QT-prolonging CYP3A4 substrates, so the combination carries a serious arrhythmia risk.
用白話說明這項交互作用的意義
Clarithromycin and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clarithromycin belongs to Anti Bacterial; Levoketoconazole belongs to Endocrine.
為什麼會發生
CYP3A4 inhibition increases clarithromycin exposure, with additive QT prolongation.
處置方式
Do not co-administer; use a non-QT-prolonging antibiotic that is not a CYP3A4 substrate or inhibitor.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Clarithromycin 的其他交互作用
Levoketoconazole 的其他交互作用
常見問題
Can I take Clarithromycin with Levoketoconazole?
MediHelp rates the interaction as contraindicated. Clarithromycin and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levoketoconazole is a strong CYP3A4 inhibitor that can raise clarithromycin levels, and both drugs prolong the QT interval. Levoketoconazole is contraindicated with other QT-prolonging CYP3A4 substrates, so the combination carries a serious arrhythmia risk.
How serious is the interaction between Clarithromycin and Levoketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use a non-QT-prolonging antibiotic that is not a CYP3A4 substrate or inhibitor.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
