藥物交互作用
Amitriptyline + Bedaquiline
嚴重程度: 嚴重
Amitriptyline and Bedaquiline: major interaction.
最後更新
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摘要
Both drugs can prolong the QT interval, so using them together raises the chance of clinically significant QTc prolongation and torsades de pointes. The risk is greater with electrolyte disturbances, cardiac disease or other QT-prolonging drugs.
用白話說明這項交互作用的意義
Amitriptyline and Bedaquiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Bedaquiline belongs to Anti Bacterial.
為什麼會發生
Additive pharmacodynamic prolongation of cardiac repolarization through blockade of cardiac potassium channels.
處置方式
Obtain a baseline ECG and repeat it periodically during co-treatment, and correct potassium, magnesium and calcium abnormalities. Stop or replace amitriptyline if QTc becomes markedly prolonged.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Amitriptyline 的其他交互作用
Bedaquiline 的其他交互作用
常見問題
Can I take Amitriptyline with Bedaquiline?
MediHelp rates the interaction as major. Amitriptyline and Bedaquiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so using them together raises the chance of clinically significant QTc prolongation and torsades de pointes. The risk is greater with electrolyte disturbances, cardiac disease or other QT-prolonging drugs.
How serious is the interaction between Amitriptyline and Bedaquiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat it periodically during co-treatment, and correct potassium, magnesium and calcium abnormalities. Stop or replace amitriptyline if QTc becomes markedly prolonged.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
