藥物交互作用
Amobarbital + Bedaquiline
嚴重程度: 嚴重
Amobarbital and Bedaquiline: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Amobarbital is a barbiturate that induces CYP3A4, the main enzyme clearing bedaquiline. Co-use can lower bedaquiline exposure and risk reduced antimycobacterial activity and treatment failure or resistance.
用白話說明這項交互作用的意義
Amobarbital and Bedaquiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Bedaquiline belongs to Anti Bacterial.
為什麼會發生
Barbiturate-mediated induction of CYP3A4 increases bedaquiline metabolism and lowers plasma concentrations.
處置方式
Avoid combining with amobarbital; choose a non-inducing sedative or anticonvulsant. If unavoidable, monitor treatment response closely.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Amobarbital 的其他交互作用
Bedaquiline 的其他交互作用
常見問題
Can I take Amobarbital with Bedaquiline?
MediHelp rates the interaction as major. Amobarbital and Bedaquiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amobarbital is a barbiturate that induces CYP3A4, the main enzyme clearing bedaquiline. Co-use can lower bedaquiline exposure and risk reduced antimycobacterial activity and treatment failure or resistance.
How serious is the interaction between Amobarbital and Bedaquiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining with amobarbital; choose a non-inducing sedative or anticonvulsant. If unavoidable, monitor treatment response closely.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
