藥物交互作用
Amiodarone + Bedaquiline
嚴重程度: 嚴重
Amiodarone and Bedaquiline: major interaction.
最後更新
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摘要
Both drugs prolong the QT interval, and amiodarone has a very long half-life so its effect persists after discontinuation. Combined use raises the risk of torsades de pointes and other serious ventricular arrhythmias.
用白話說明這項交互作用的意義
Amiodarone and Bedaquiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Bedaquiline belongs to Anti Bacterial.
為什麼會發生
Additive QTc prolongation through pharmacodynamic effects on cardiac repolarization.
處置方式
Avoid the combination where an alternative exists; if essential, obtain a baseline ECG and repeat it regularly, and keep potassium, magnesium and calcium within normal ranges. Stop bedaquiline if significant QTc prolongation or ventricular arrhythmia develops.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Amiodarone 的其他交互作用
Bedaquiline 的其他交互作用
常見問題
Can I take Amiodarone with Bedaquiline?
MediHelp rates the interaction as major. Amiodarone and Bedaquiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, and amiodarone has a very long half-life so its effect persists after discontinuation. Combined use raises the risk of torsades de pointes and other serious ventricular arrhythmias.
How serious is the interaction between Amiodarone and Bedaquiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative exists; if essential, obtain a baseline ECG and repeat it regularly, and keep potassium, magnesium and calcium within normal ranges. Stop bedaquiline if significant QTc prolongation or ventricular arrhythmia develops.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
