藥物交互作用
Amitriptyline + Dexchlorpheniramine
嚴重程度: 中度
Amitriptyline and Dexchlorpheniramine: moderate interaction.
最後更新
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摘要
Dexchlorpheniramine is a first-generation antihistamine with sedative and anticholinergic properties like amitriptyline. Together they can increase drowsiness, dry mouth, urinary retention, and confusion.
用白話說明這項交互作用的意義
Amitriptyline and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Dexchlorpheniramine belongs to Respiratory.
為什麼會發生
Additive CNS depression and antimuscarinic effects.
處置方式
Monitor for sedation and anticholinergic effects, especially in older patients. Switch to a non-sedating antihistamine if appropriate.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Amitriptyline 的其他交互作用
Dexchlorpheniramine 的其他交互作用
常見問題
Can I take Amitriptyline with Dexchlorpheniramine?
MediHelp rates the interaction as moderate. Amitriptyline and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexchlorpheniramine is a first-generation antihistamine with sedative and anticholinergic properties like amitriptyline. Together they can increase drowsiness, dry mouth, urinary retention, and confusion.
How serious is the interaction between Amitriptyline and Dexchlorpheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and anticholinergic effects, especially in older patients. Switch to a non-sedating antihistamine if appropriate.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
