藥物交互作用
Amlodipine-benazepril + Canagliflozin
嚴重程度: 中度
Amlodipine-benazepril and Canagliflozin: moderate interaction.
最後更新
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摘要
Canagliflozin does not typically raise potassium in the way potassium-sparing agents do, and it may even lower hyperkalemia risk. The more relevant concern is additive volume depletion and hypotension with benazepril, with possible effects on renal function.
用白話說明這項交互作用的意義
Amlodipine-benazepril and Canagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Canagliflozin belongs to Endocrine.
為什麼會發生
Additive hypotensive and volume-depleting effects from osmotic diuresis plus RAAS inhibition.
處置方式
Assess volume status and monitor blood pressure, creatinine and potassium after starting canagliflozin. Reduce diuretic or antihypertensive doses if hypovolemia develops.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Amlodipine-benazepril 的其他交互作用
Canagliflozin 的其他交互作用
常見問題
Can I take Amlodipine-benazepril with Canagliflozin?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Canagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin does not typically raise potassium in the way potassium-sparing agents do, and it may even lower hyperkalemia risk. The more relevant concern is additive volume depletion and hypotension with benazepril, with possible effects on renal function.
How serious is the interaction between Amlodipine-benazepril and Canagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status and monitor blood pressure, creatinine and potassium after starting canagliflozin. Reduce diuretic or antihypertensive doses if hypovolemia develops.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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