藥物交互作用
Amlodipine-olmesartan-hydrochlorothiazide + Canagliflozin
嚴重程度: 中度
Amlodipine-olmesartan-hydrochlorothiazide and Canagliflozin: moderate interaction.
最後更新
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摘要
Canagliflozin causes osmotic diuresis and can add to the volume depletion and blood pressure lowering of an ARB and thiazide, with a risk of hypotension and acute kidney injury. Canagliflozin may also modestly increase potassium in some patients, especially with an ARB and renal impairment.
用白話說明這項交互作用的意義
Amlodipine-olmesartan-hydrochlorothiazide and Canagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Canagliflozin belongs to Endocrine.
為什麼會發生
Additive diuretic and hypotensive effects, with possible additive effects on potassium and renal hemodynamics.
處置方式
Assess volume status before starting canagliflozin and consider reducing the diuretic dose. Monitor blood pressure, renal function and potassium.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Amlodipine-olmesartan-hydrochlorothiazide 的其他交互作用
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide 禁忌併用
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide 禁忌併用
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan 禁忌併用
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide 嚴重
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide 嚴重
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide 嚴重
Canagliflozin 的其他交互作用
常見問題
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Canagliflozin?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Canagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin causes osmotic diuresis and can add to the volume depletion and blood pressure lowering of an ARB and thiazide, with a risk of hypotension and acute kidney injury. Canagliflozin may also modestly increase potassium in some patients, especially with an ARB and renal impairment.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Canagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status before starting canagliflozin and consider reducing the diuretic dose. Monitor blood pressure, renal function and potassium.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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