藥物交互作用
Amlodipine-olmesartan + Canagliflozin
嚴重程度: 中度
Amlodipine-olmesartan and Canagliflozin: moderate interaction.
最後更新
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摘要
Canagliflozin can cause volume depletion and hypotension, and with olmesartan may increase the risk of acute kidney injury. Canagliflozin has been associated with small rises in potassium, mainly in renally impaired patients taking RAAS inhibitors.
用白話說明這項交互作用的意義
Amlodipine-olmesartan and Canagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Canagliflozin belongs to Endocrine.
為什麼會發生
Additive effects of osmotic diuresis and renin-angiotensin blockade on volume status and renal hemodynamics.
處置方式
Assess volume status and renal function before starting canagliflozin and monitor creatinine, potassium and blood pressure afterward. Reduce antihypertensive or diuretic doses if hypotension occurs.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Amlodipine-olmesartan 的其他交互作用
Canagliflozin 的其他交互作用
常見問題
Can I take Amlodipine-olmesartan with Canagliflozin?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Canagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin can cause volume depletion and hypotension, and with olmesartan may increase the risk of acute kidney injury. Canagliflozin has been associated with small rises in potassium, mainly in renally impaired patients taking RAAS inhibitors.
How serious is the interaction between Amlodipine-olmesartan and Canagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status and renal function before starting canagliflozin and monitor creatinine, potassium and blood pressure afterward. Reduce antihypertensive or diuretic doses if hypotension occurs.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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