藥物交互作用
Amlodipine-hydrochlorothiazide-valsartan + Colestipol
嚴重程度: 中度
Amlodipine-hydrochlorothiazide-valsartan and Colestipol: moderate interaction.
最後更新
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摘要
Colestipol is a bile acid sequestrant that binds hydrochlorothiazide in the gut and reduces its absorption. This can lower the diuretic and antihypertensive effect of the thiazide.
用白話說明這項交互作用的意義
Amlodipine-hydrochlorothiazide-valsartan and Colestipol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Colestipol belongs to Cardiovascular.
為什麼會發生
Binding of hydrochlorothiazide by the resin in the gastrointestinal tract, reducing absorption.
處置方式
Give the hydrochlorothiazide-containing product at least 2 hours before or 4 to 6 hours after colestipol, and monitor blood pressure.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Amlodipine-hydrochlorothiazide-valsartan 的其他交互作用
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan 禁忌併用
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide 禁忌併用
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan 禁忌併用
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan 嚴重
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan 嚴重
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan 嚴重
Colestipol 的其他交互作用
常見問題
Can I take Amlodipine-hydrochlorothiazide-valsartan with Colestipol?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Colestipol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colestipol is a bile acid sequestrant that binds hydrochlorothiazide in the gut and reduces its absorption. This can lower the diuretic and antihypertensive effect of the thiazide.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Colestipol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the hydrochlorothiazide-containing product at least 2 hours before or 4 to 6 hours after colestipol, and monitor blood pressure.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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