藥物交互作用
Atenolol-chlorthalidone + Colestipol
嚴重程度: 中度
Atenolol-chlorthalidone and Colestipol: moderate interaction.
最後更新
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摘要
Colestipol is a bile acid sequestrant that binds to acidic drugs in the gut and can reduce absorption of thiazide-type diuretics. This may weaken the diuretic and antihypertensive effect of chlorthalidone.
用白話說明這項交互作用的意義
Atenolol-chlorthalidone and Colestipol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Colestipol belongs to Cardiovascular.
為什麼會發生
Binding of chlorthalidone in the gastrointestinal tract, reducing its absorption.
處置方式
Give atenolol-chlorthalidone at least 1 hour before or 4 hours after colestipol. Monitor blood pressure.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Atenolol-chlorthalidone 的其他交互作用
Colestipol 的其他交互作用
常見問題
Can I take Atenolol-chlorthalidone with Colestipol?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Colestipol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colestipol is a bile acid sequestrant that binds to acidic drugs in the gut and can reduce absorption of thiazide-type diuretics. This may weaken the diuretic and antihypertensive effect of chlorthalidone.
How serious is the interaction between Atenolol-chlorthalidone and Colestipol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give atenolol-chlorthalidone at least 1 hour before or 4 hours after colestipol. Monitor blood pressure.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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