藥物交互作用
Efavirenz + Isavuconazonium
嚴重程度: 禁忌併用
Efavirenz and Isavuconazonium: contraindicated interaction.
最後更新
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摘要
Efavirenz may reduce isavuconazole concentrations, risking treatment failure of serious invasive fungal infections. Strong inducers are contraindicated with isavuconazonium.
用白話說明這項交互作用的意義
Efavirenz and Isavuconazonium are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Efavirenz belongs to Anti Virals; Isavuconazonium belongs to Anti Fungals.
為什麼會發生
Efavirenz induces CYP3A4 metabolism of isavuconazole.
處置方式
Avoid the combination; use an alternative antifungal or antiretroviral. If unavoidable, monitor isavuconazole levels and clinical response.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Efavirenz 的其他交互作用
Isavuconazonium 的其他交互作用
常見問題
Can I take Efavirenz with Isavuconazonium?
MediHelp rates the interaction as contraindicated. Efavirenz and Isavuconazonium are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Efavirenz may reduce isavuconazole concentrations, risking treatment failure of serious invasive fungal infections. Strong inducers are contraindicated with isavuconazonium.
How serious is the interaction between Efavirenz and Isavuconazonium?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an alternative antifungal or antiretroviral. If unavoidable, monitor isavuconazole levels and clinical response.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
