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Carbamazepine + Isavuconazonium

嚴重程度: 禁忌併用

Carbamazepine and Isavuconazonium: contraindicated interaction.

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僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

Carbamazepine induces CYP3A4 and greatly reduces isavuconazole exposure, risking treatment failure of serious fungal infection. Labeling contraindicates strong CYP3A4 inducers.

用白話說明這項交互作用的意義

Carbamazepine and Isavuconazonium are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Carbamazepine belongs to Central Nervous System; Isavuconazonium belongs to Anti Fungals.

證據等級: High

為什麼會發生

Carbamazepine induces CYP3A4, increasing isavuconazole clearance.

處置方式

Do not coadminister; use a non-inducing anticonvulsant or an alternative antifungal.

可向藥師詢問的問題

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可解鎖 Carbamazepine 與 Isavuconazonium 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
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常見問題

Can I take Carbamazepine with Isavuconazonium?

MediHelp rates the interaction as contraindicated. Carbamazepine and Isavuconazonium are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Carbamazepine induces CYP3A4 and greatly reduces isavuconazole exposure, risking treatment failure of serious fungal infection. Labeling contraindicates strong CYP3A4 inducers.

How serious is the interaction between Carbamazepine and Isavuconazonium?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use a non-inducing anticonvulsant or an alternative antifungal.

What other medicines interact with Carbamazepine?

MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.

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