藥物交互作用
Amobarbital + Levonorgestrel
嚴重程度: 嚴重
Amobarbital and Levonorgestrel: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Barbiturates can lower levonorgestrel concentrations and may cause contraceptive failure, including with emergency contraception.
用白話說明這項交互作用的意義
Amobarbital and Levonorgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Levonorgestrel belongs to Endocrine.
為什麼會發生
Barbiturate induction of CYP3A4 accelerates levonorgestrel metabolism.
處置方式
Use an additional non-hormonal method or a non-affected method such as a copper IUD; for emergency contraception, consider a copper IUD or a higher levonorgestrel dose per local guidance.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Amobarbital 的其他交互作用
Levonorgestrel 的其他交互作用
常見問題
Can I take Amobarbital with Levonorgestrel?
MediHelp rates the interaction as major. Amobarbital and Levonorgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates can lower levonorgestrel concentrations and may cause contraceptive failure, including with emergency contraception.
How serious is the interaction between Amobarbital and Levonorgestrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an additional non-hormonal method or a non-affected method such as a copper IUD; for emergency contraception, consider a copper IUD or a higher levonorgestrel dose per local guidance.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
