藥物交互作用
Brigatinib + Levonorgestrel
嚴重程度: 嚴重
Brigatinib and Levonorgestrel: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Brigatinib may lower hormonal contraceptive concentrations and lead to loss of contraceptive efficacy. Pregnancy during brigatinib therapy is a concern because of fetal harm.
用白話說明這項交互作用的意義
Brigatinib and Levonorgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brigatinib belongs to Oncology; Levonorgestrel belongs to Endocrine.
為什麼會發生
Brigatinib induces CYP3A4, accelerating levonorgestrel metabolism.
處置方式
Use an effective non-hormonal contraceptive during treatment and for at least 4 months after the last dose.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Levonorgestrel 的其他交互作用
Brigatinib 的其他交互作用
常見問題
Can I take Brigatinib with Levonorgestrel?
MediHelp rates the interaction as major. Brigatinib and Levonorgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brigatinib may lower hormonal contraceptive concentrations and lead to loss of contraceptive efficacy. Pregnancy during brigatinib therapy is a concern because of fetal harm.
How serious is the interaction between Brigatinib and Levonorgestrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an effective non-hormonal contraceptive during treatment and for at least 4 months after the last dose.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
