藥物交互作用
Bosentan + Levonorgestrel
嚴重程度: 嚴重
Bosentan and Levonorgestrel: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Bosentan induces CYP3A4 and may lower systemic levonorgestrel exposure from oral or emergency products. The intrauterine system acts mainly locally and is much less affected, so the concern is mainly for systemic formulations, and bosentan is teratogenic.
用白話說明這項交互作用的意義
Bosentan and Levonorgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosentan belongs to Miscellaneous; Levonorgestrel belongs to Endocrine.
為什麼會發生
Bosentan induces CYP3A4, increasing the metabolism of levonorgestrel.
處置方式
Use a reliable method that does not depend on systemic hormone levels, such as an intrauterine system or copper IUD, rather than oral levonorgestrel alone. Consider a higher emergency contraception dose or a copper IUD for emergency use.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Levonorgestrel 的其他交互作用
Bosentan 的其他交互作用
常見問題
Can I take Bosentan with Levonorgestrel?
MediHelp rates the interaction as major. Bosentan and Levonorgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bosentan induces CYP3A4 and may lower systemic levonorgestrel exposure from oral or emergency products. The intrauterine system acts mainly locally and is much less affected, so the concern is mainly for systemic formulations, and bosentan is teratogenic.
How serious is the interaction between Bosentan and Levonorgestrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a reliable method that does not depend on systemic hormone levels, such as an intrauterine system or copper IUD, rather than oral levonorgestrel alone. Consider a higher emergency contraception dose or a copper IUD for emergency use.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
