藥物交互作用
Anti-inhibitor coagulant complex + Tranexamic acid
嚴重程度: 嚴重
Anti-inhibitor coagulant complex and Tranexamic acid: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Tranexamic acid blocks fibrinolysis while anti-inhibitor coagulant complex (activated prothrombin complex concentrate) promotes clot formation. Together they raise the risk of thrombotic events, including venous thrombosis and myocardial infarction.
用白話說明這項交互作用的意義
Anti-inhibitor coagulant complex and Tranexamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive prothrombotic effect from antifibrinolytic action combined with a procoagulant product.
處置方式
Avoid concurrent use, or give tranexamic acid no sooner than about 6 to 12 hours after the complex per labeling. Monitor for signs of thrombosis.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Tranexamic acid 的其他交互作用
常見問題
Can I take Anti-inhibitor coagulant complex with Tranexamic acid?
MediHelp rates the interaction as major. Anti-inhibitor coagulant complex and Tranexamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tranexamic acid blocks fibrinolysis while anti-inhibitor coagulant complex (activated prothrombin complex concentrate) promotes clot formation. Together they raise the risk of thrombotic events, including venous thrombosis and myocardial infarction.
How serious is the interaction between Anti-inhibitor coagulant complex and Tranexamic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use, or give tranexamic acid no sooner than about 6 to 12 hours after the complex per labeling. Monitor for signs of thrombosis.
What other medicines interact with Tranexamic acid?
MediHelp also lists interactions of Tranexamic acid with, for example, Dienogest / estradiol valerate, Ethinyl estradiol-drospirenone, Ethinyl estradiol-levonorgestrel. The full list is on the Tranexamic acid page.
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