藥物交互作用
Cobicistat + Eletriptan
嚴重程度: 禁忌併用
Cobicistat and Eletriptan: contraindicated interaction.
最後更新
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摘要
Cobicistat is a strong CYP3A4 inhibitor and markedly raises eletriptan exposure, which increases the risk of triptan toxicity including vasoconstriction and hypertension. Eletriptan labeling contraindicates use with strong CYP3A4 inhibitors.
用白話說明這項交互作用的意義
Cobicistat and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cobicistat belongs to Miscellaneous; Eletriptan belongs to Central Nervous System.
為什麼會發生
Inhibition of CYP3A4-mediated metabolism of eletriptan, increasing its plasma concentrations.
處置方式
Do not use eletriptan during or within about 72 hours of cobicistat. Use a triptan not dependent on CYP3A4, such as rizatriptan or sumatriptan, if one is needed.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Eletriptan 的其他交互作用
Cobicistat 的其他交互作用
常見問題
Can I take Cobicistat with Eletriptan?
MediHelp rates the interaction as contraindicated. Cobicistat and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cobicistat is a strong CYP3A4 inhibitor and markedly raises eletriptan exposure, which increases the risk of triptan toxicity including vasoconstriction and hypertension. Eletriptan labeling contraindicates use with strong CYP3A4 inhibitors.
How serious is the interaction between Cobicistat and Eletriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use eletriptan during or within about 72 hours of cobicistat. Use a triptan not dependent on CYP3A4, such as rizatriptan or sumatriptan, if one is needed.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
