藥物交互作用
Cobicistat + Colchicine
嚴重程度: 禁忌併用
Cobicistat and Colchicine: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Cobicistat strongly inhibits CYP3A4 and P-glycoprotein, markedly increasing colchicine exposure. This can lead to life-threatening colchicine toxicity, and the combination is contraindicated in patients with renal or hepatic impairment.
用白話說明這項交互作用的意義
Cobicistat and Colchicine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cobicistat belongs to Miscellaneous; Colchicine belongs to Genitourinary.
為什麼會發生
Inhibition of CYP3A4 and P-glycoprotein reduces colchicine metabolism and efflux.
處置方式
Do not use together in patients with renal or hepatic impairment. In others, reduce the colchicine dose substantially as per labeling and monitor for toxicity.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Colchicine 的其他交互作用
Cobicistat 的其他交互作用
常見問題
Can I take Cobicistat with Colchicine?
MediHelp rates the interaction as contraindicated. Cobicistat and Colchicine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cobicistat strongly inhibits CYP3A4 and P-glycoprotein, markedly increasing colchicine exposure. This can lead to life-threatening colchicine toxicity, and the combination is contraindicated in patients with renal or hepatic impairment.
How serious is the interaction between Cobicistat and Colchicine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together in patients with renal or hepatic impairment. In others, reduce the colchicine dose substantially as per labeling and monitor for toxicity.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cyclosporine, Ensitrelvir. The full list is on the Colchicine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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