藥物交互作用
Apalutamide + Leniolisib
嚴重程度: 嚴重
Apalutamide and Leniolisib: major interaction.
最後更新
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摘要
Apalutamide may substantially lower leniolisib exposure since leniolisib is cleared mainly by CYP3A4. Reduced exposure could compromise control of activated PI3K delta syndrome.
用白話說明這項交互作用的意義
Apalutamide and Leniolisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Leniolisib belongs to Miscellaneous.
為什麼會發生
CYP3A4 induction by apalutamide increases leniolisib metabolism.
處置方式
Avoid combining with strong CYP3A4 inducers as advised in leniolisib labeling. If unavoidable, monitor for loss of clinical effect.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Apalutamide 的其他交互作用
Leniolisib 的其他交互作用
常見問題
Can I take Apalutamide with Leniolisib?
MediHelp rates the interaction as major. Apalutamide and Leniolisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide may substantially lower leniolisib exposure since leniolisib is cleared mainly by CYP3A4. Reduced exposure could compromise control of activated PI3K delta syndrome.
How serious is the interaction between Apalutamide and Leniolisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining with strong CYP3A4 inducers as advised in leniolisib labeling. If unavoidable, monitor for loss of clinical effect.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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