藥物交互作用
Crizotinib + Lonafarnib
嚴重程度: 禁忌併用
Crizotinib and Lonafarnib: contraindicated interaction.
最後更新
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摘要
Lonafarnib is a sensitive CYP3A4 substrate, and crizotinib is a moderate CYP3A4 inhibitor, so lonafarnib exposure may increase considerably. This raises the risk of toxicity such as gastrointestinal effects, hepatotoxicity and QT prolongation.
用白話說明這項交互作用的意義
Crizotinib and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Crizotinib belongs to Oncology; Lonafarnib belongs to Miscellaneous.
為什麼會發生
Crizotinib inhibits CYP3A4-mediated metabolism of lonafarnib.
處置方式
Avoid the combination in line with lonafarnib labeling for CYP3A inhibitors. If it cannot be avoided, a specialist should guide dose reduction and monitoring.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Crizotinib 的其他交互作用
Lonafarnib 的其他交互作用
常見問題
Can I take Crizotinib with Lonafarnib?
MediHelp rates the interaction as contraindicated. Crizotinib and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lonafarnib is a sensitive CYP3A4 substrate, and crizotinib is a moderate CYP3A4 inhibitor, so lonafarnib exposure may increase considerably. This raises the risk of toxicity such as gastrointestinal effects, hepatotoxicity and QT prolongation.
How serious is the interaction between Crizotinib and Lonafarnib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in line with lonafarnib labeling for CYP3A inhibitors. If it cannot be avoided, a specialist should guide dose reduction and monitoring.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Pimozide. The full list is on the Crizotinib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
