藥物交互作用
Apixaban + Rifabutin
嚴重程度: 嚴重
Apixaban and Rifabutin: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Rifabutin induces drug-metabolising enzymes and speeds up clearance of apixaban. Reduced apixaban exposure leaves patients less protected against stroke or venous thromboembolism.
用白話說明這項交互作用的意義
Apixaban and Rifabutin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apixaban belongs to Cardiovascular; Rifabutin belongs to Anti Bacterial.
為什麼會發生
CYP3A4/P-gp induction lowers apixaban exposure
處置方式
Avoid with potent inducers; if essential, monitor for thrombosis and consider an alternative anticoagulant.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Apixaban 的其他交互作用
Rifabutin 的其他交互作用
常見問題
Can I take Apixaban with Rifabutin?
MediHelp rates the interaction as major. Apixaban and Rifabutin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifabutin induces drug-metabolising enzymes and speeds up clearance of apixaban. Reduced apixaban exposure leaves patients less protected against stroke or venous thromboembolism.
How serious is the interaction between Apixaban and Rifabutin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid with potent inducers; if essential, monitor for thrombosis and consider an alternative anticoagulant.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
