藥物交互作用
Lorlatinib + Rifabutin
嚴重程度: 禁忌併用
Lorlatinib and Rifabutin: contraindicated interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Rifabutin induces CYP3A4 and can lower lorlatinib exposure, risking loss of efficacy. Strong CYP3A inducers given with lorlatinib have been associated with raised liver enzymes. Labeling prohibits the combination.
用白話說明這項交互作用的意義
Lorlatinib and Rifabutin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lorlatinib belongs to Oncology; Rifabutin belongs to Anti Bacterial.
為什麼會發生
CYP3A4 induction increases lorlatinib metabolism and lowers its plasma concentration.
處置方式
Do not use together; choose a non-inducing alternative for the indication. If an inducer is necessary, stop it for about 3 half-lives before lorlatinib.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Lorlatinib 的其他交互作用
Rifabutin 的其他交互作用
常見問題
Can I take Lorlatinib with Rifabutin?
MediHelp rates the interaction as contraindicated. Lorlatinib and Rifabutin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rifabutin induces CYP3A4 and can lower lorlatinib exposure, risking loss of efficacy. Strong CYP3A inducers given with lorlatinib have been associated with raised liver enzymes. Labeling prohibits the combination.
How serious is the interaction between Lorlatinib and Rifabutin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose a non-inducing alternative for the indication. If an inducer is necessary, stop it for about 3 half-lives before lorlatinib.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
