藥物交互作用
Rifabutin + Voriconazole
嚴重程度: 禁忌併用
Rifabutin and Voriconazole: contraindicated interaction.
最後更新
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摘要
Rifabutin induces voriconazole metabolism and can lower antifungal levels enough to cause treatment failure. Voriconazole also increases rifabutin exposure, raising the risk of uveitis and neutropenia.
用白話說明這項交互作用的意義
Rifabutin and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Rifabutin belongs to Anti Bacterial; Voriconazole belongs to Anti Fungals.
為什麼會發生
Rifabutin induces CYP450 enzymes lowering voriconazole, while voriconazole inhibits CYP3A4 raising rifabutin.
處置方式
Avoid the combination under labeling. If essential, use specialist guidance with voriconazole dose adjustment, therapeutic drug monitoring and monitoring for rifabutin toxicity.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Voriconazole 的其他交互作用
Rifabutin 的其他交互作用
常見問題
Can I take Rifabutin with Voriconazole?
MediHelp rates the interaction as contraindicated. Rifabutin and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rifabutin induces voriconazole metabolism and can lower antifungal levels enough to cause treatment failure. Voriconazole also increases rifabutin exposure, raising the risk of uveitis and neutropenia.
How serious is the interaction between Rifabutin and Voriconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination under labeling. If essential, use specialist guidance with voriconazole dose adjustment, therapeutic drug monitoring and monitoring for rifabutin toxicity.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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