藥物交互作用
Apraclonidine + Rasagiline
嚴重程度: 嚴重
Apraclonidine and Rasagiline: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Apraclonidine labeling advises against use in patients taking MAO inhibitors. Theoretically, MAO inhibition could alter catecholamine handling and cause blood pressure changes, though ophthalmic systemic exposure is small.
用白話說明這項交互作用的意義
Apraclonidine and Rasagiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apraclonidine belongs to Cardiovascular; Rasagiline belongs to Central Nervous System.
為什麼會發生
Not firmly established; reduced catecholamine metabolism by MAO inhibition may potentiate the cardiovascular effects of the alpha-2 agonist.
處置方式
Avoid apraclonidine in patients on rasagiline and select another intraocular pressure agent. If unavoidable, monitor blood pressure and heart rate.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Rasagiline 的其他交互作用
Apraclonidine 的其他交互作用
常見問題
Can I take Apraclonidine with Rasagiline?
MediHelp rates the interaction as major. Apraclonidine and Rasagiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apraclonidine labeling advises against use in patients taking MAO inhibitors. Theoretically, MAO inhibition could alter catecholamine handling and cause blood pressure changes, though ophthalmic systemic exposure is small.
How serious is the interaction between Apraclonidine and Rasagiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid apraclonidine in patients on rasagiline and select another intraocular pressure agent. If unavoidable, monitor blood pressure and heart rate.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
