藥物交互作用
Apraclonidine + Tranylcypromine
嚴重程度: 嚴重
Apraclonidine and Tranylcypromine: major interaction.
最後更新
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摘要
Apraclonidine is an alpha-2 agonist eye drop with limited systemic exposure, but labeling contraindicates its use with MAOIs. MAOIs may alter catecholamine handling and unpredictably change blood pressure responses.
用白話說明這項交互作用的意義
Apraclonidine and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apraclonidine belongs to Cardiovascular; Tranylcypromine belongs to Central Nervous System.
為什麼會發生
The mechanism is not well established; MAOI-related changes in catecholamine metabolism may alter responses to alpha-agonists.
處置方式
Avoid apraclonidine in patients on tranylcypromine and select another ocular hypotensive agent such as a prostaglandin analogue or beta-blocker as appropriate. If it is unavoidable, monitor blood pressure and heart rate.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Tranylcypromine 的其他交互作用
Apraclonidine 的其他交互作用
常見問題
Can I take Apraclonidine with Tranylcypromine?
MediHelp rates the interaction as major. Apraclonidine and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apraclonidine is an alpha-2 agonist eye drop with limited systemic exposure, but labeling contraindicates its use with MAOIs. MAOIs may alter catecholamine handling and unpredictably change blood pressure responses.
How serious is the interaction between Apraclonidine and Tranylcypromine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid apraclonidine in patients on tranylcypromine and select another ocular hypotensive agent such as a prostaglandin analogue or beta-blocker as appropriate. If it is unavoidable, monitor blood pressure and heart rate.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
